Mark D Distefano Selected Research

Neoplasms (Cancer)

5/2024	Targeted Drug Delivery by MMAE Farnesyl-Bioconjugated Multivalent Chemically Self-Assembled Nanorings Induces Potent Receptor-Dependent Immunogenic Cell Death.
4/2024	Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry.
1/2023	GTPase splice variants RAC1 and RAC1B display isoform-specific differences in localization, prenylation, and interaction with the chaperone protein SmgGDS.
10/2022	Manipulating Cell Fates with Protein Conjugates.
9/2022	Enzymatic Construction of DARPin-Based Targeted Delivery Systems Using Protein Farnesyltransferase and a Capture and Release Strategy.
1/2020	Anti-EGFR Fibronectin Bispecific Chemically Self-Assembling Nanorings (CSANs) Induce Potent T Cell-Mediated Antitumor Responses and Downregulation of EGFR Signaling and PD-1/PD-L1 Expression.
1/2020	Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy.
1/2018	Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.
1/2017	a-Factor: a chemical biology tool for the study of protein prenylation.
1/2016	8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells.

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Mark D Distefano Research Topics

Disease

17	Neoplasms (Cancer) 05/2024 - 07/2003
3	Progeria (Hutchinson Gilford Syndrome) 01/2018 - 03/2013
2	Alzheimer Disease (Alzheimer's Disease) 10/2022 - 01/2018
2	Carcinoma (Carcinomatosis) 11/2016 - 01/2016
2	Parasitic Diseases (Parasitic Disease) 01/2015 - 03/2013
1	Hypercholesterolemia 05/2024
1	Sepsis (Septicemia) 05/2024
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2023
1	Carcinogenesis 01/2020
1	Lung Neoplasms (Lung Cancer) 01/2020
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2020
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2018
1	Breast Neoplasms (Breast Cancer) 01/2018
1	Infectious Bone Diseases 01/2018
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018
1	Malaria 12/2016
1	Noncommunicable Diseases 06/2015
1	Opioid-Related Disorders (Opiate Addiction) 06/2015
1	Virus Diseases (Viral Diseases) 01/2015
1	Leukemia 11/2013
1	Hepatitis C 03/2013
1	Infections 12/2008
1	Melanoma (Melanoma, Malignant) 07/2003

Drug/Important Bio-Agent (IBA)

7	Proteins (Proteins, Gene)FDA Link 01/2023 - 07/2003
4	Dimethylallyltranstransferase (Dimethylallyltransferase)IBA 12/2016 - 03/2013
3	ras ProteinsIBA 01/2017 - 08/2010
3	Peptides (Polypeptides)IBA 01/2017 - 07/2003
2	Monomeric GTP-Binding ProteinsIBA 01/2023 - 01/2020
2	ErbB Receptors (EGF Receptor)IBA 01/2020 - 01/2018
2	Farnesyltranstransferase (Farnesyltransferase)IBA 01/2016 - 08/2010
2	EnzymesIBA 01/2016 - 01/2014
1	Mevalonic Acid (Mevalonate)IBA 05/2024
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 05/2024
1	AntigensIBA 05/2024
1	PolymersIBA 04/2024
1	Designed Ankyrin Repeat ProteinsIBA 09/2022
1	Epithelial Cell Adhesion MoleculeIBA 09/2022
1	Protein Isoforms (Isoforms)IBA 01/2020
1	Terpenes (Terpenoids)IBA 01/2018
1	HydrogelsIBA 01/2018
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2018
1	Epidermal Growth Factor (EGF)IBA 01/2018
1	Cysteine (L-Cysteine)FDA Link 01/2017
1	Complement System Proteins (Complement)IBA 12/2016
1	Antimalarials (Antimalarial Agents)IBA 12/2016
1	Small Interfering RNA (siRNA)IBA 01/2016
1	HaptensIBA 06/2015
1	VaccinesIBA 06/2015
1	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 11/2013
1	Therapeutic UsesIBA 03/2013
1	Diphosphates (Pyrophosphates)IBA 12/2008
1	prenylIBA 12/2008
1	p21(ras) farnesyl-protein transferase (protein farnesyltransferase)IBA 09/2008
1	Apoptosis Regulatory ProteinsIBA 07/2003

Therapy/Procedure

4	Therapeutics 01/2016 - 03/2013
1	Immunotherapy 01/2020